First real-world cohort in Brazil.

Includes all patients from the Memory Center at Hospital Moinhos de Vento who consent to participate in the cohort.

Objectives: prevention, diagnosis, and potentially treatment of neurodegenerative pathologies.

• Prevention: understanding risk factors and determinants of cognitive health in the population
• Diagnosis: investigating new diagnostic methods and workflows with greater accuracy
• Treatment: assessing patient eligibility according to clinical trial criteria and novel treatments for neurodegenerative diseases
• Mechanism: evaluating the moderating, direct, or indirect effects of copathologies and multimorbidities on cognitive outcomes

Baseline assessment: sociodemographic data, anthropometry, MMSE, MoCA, FAQ, QDRS, risk factors (24 factors), adjudicated clinical diagnosis

Cognitive assessment: memory, language, executive functions, visuospatial functions, attention, social cognition

Neuroimaging assessment: structural MRI, ASL, DTI, PET-FBB, PET-FDG

Biofluid biobank: blood, plasma, CSF